NFL Week 1 odds are now available as rookies begin to report to training camps this week. With all NFL teams expected to start training camp within the next week, betting odds for Week 1 games are likely to fluctuate as practices and preseason games unfold.
The season kicks off on Thursday, September 5, with the Baltimore Ravens as +3 underdogs against the defending Super Bowl champions, the Kansas City Chiefs (-2.5). On Friday, the Green Bay Packers (+1.5) will face off against the Philadelphia Eagles (-1) in a rare game taking place in Brazil.
Week 1 concludes with the defending NFC champion San Francisco 49ers (-5.5) hosting the New York Jets (+5.5) on the first Monday Night Football of the season. For a comprehensive look at every Week 1 matchup and the full betting odds, see below.
Opening Spreads, Betting Lines, and Totals for NFL Week 1
| Matchup | Spread | Moneyline | Over/Under |
| Baltimore Ravens at Kansas City Chiefs | Chiefs -2.5 | Ravens +130/Chiefs -144 | 47 |
| Green Bay Packers at Philadelphia Eagles | Eagles -1.5 | Packers +105/Eagles -120 | 48.5 |
| Jacksonville Jaguars at Miami Dolphins | Dolphins -3.5 | Jaguars +150/Dolphins -178 | 48 |
| Carolina Panthers at New Orleans Saints | Saints -4.5 | Panthers +194/Saints -205 | 40.5 |
| Minnesota Vikings at New York Giants | Giants +1 | Vikings -108/Giants -108 | 41.5 |
| Tennessee Titans at Chicago Bears | Bears -4.5 | Titans +188/Bears -208 | 43.5 |
| New England Patriots at Cincinnati Bengals | Bengals -9 | Patriots +350/Bengals -410 | 43 |
| Houston Texans at Indianapolis Colts | Texans -1.5 | Texans -122/Colts +110 | 48 |
| Arizona Cardinals at Buffalo Bills | Bills -7 | Cardinals +285/Bills -320 | 48 |
| Pittsburgh Steelers at Atlanta Falcons | Falcons -2.5 | Steelers +120/Falcons -140 | 43 |
| Denver Broncos at Seattle Seahawks | Seahawks -4.5 | Broncos +194/Seahawks -218 | 42.5 |
| Las Vegas Raiders at Los Angeles Chargers | Chargers -3 | Raiders +155/Chargers -170 | 43.5 |
| Washington Commanders at Tampa Bay Buccaneers | Buccaneers -3.5 | Commanders +154/Buccaneers -185 | 41.5 |
| Dallas Cowboys at Cleveland Browns | Browns -1 | Cowboys +100/Browns -108 | 44 |
| Los Angeles Rams at Detroit Lions | Lions -3.5 | Rams +160/Lions -180 | 51 |
| New York Jets at San Francisco 49ers | 49ers -5.5 | Jets +205/49ers -235 | 45.5 |